How https://www.ceesdekker.net can Save You Time, Stress, and Money.
How https://www.ceesdekker.net can Save You Time, Stress, and Money.
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Utilizing one-molecule optical and AFM imaging and pressure-spectroscopy strategies, we look for to unravel the mechanistic components of the composition and dynamics of chromosomes. Our investigation passions consist of:
Human Rad51 filaments on double- and single-stranded DNA: correlating common and irregular forms with recombination operate.
Round the very same time, the group of Paul McEuen, who was then centered with the University of California, Berkeley, confirmed comparable results on ropes of bundled nanotubes. Depending on the wrapping angle, nanotubes can can be found in metallic or semiconducting variants, a prediction that we and Charles Lieber’s group at Harvard College independently confirmed working with scanning tunnelling spectroscopy experiments.
Non-equilibrium folding of particular person DNA molecules recaptured as many as a thousand periods in a very stable condition nanopore
We establish issue-of-treatment diagnostics examination of neglected tropical illnesses inside resource-minimal configurations, based on Crspr/Cas9 detecting of pathogen’s DNA in system fluids.
Example (three) of bending configurations in 3D simulations of DNA rods on nanopores. A portion of the membrane is shown in gray, the rim in the pore is highlighted in red, and also a 3D rendering in the movement on the DNA rod is displayed.
Considering the fact that 2000 he moved to one-molecule biophysics and nanobiology, with investigate from DNA supercoiling scientific studies of nucleosomes and DNA restore proteins to DNA translocation through nanopores. Not long ago his exploration has centered on cees dekker finding out cell division with bacteria on chip, whilst his best desire is in the route of realizing artificial cells.
Atomic pressure microscopy shows that vaccinia topoisomerase IB generates filaments on DNA within a cooperative vogue
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Dekker commenced his study on one carbon nanotubes in 1993 when he put in place a fresh line of study to check electrical transport through solitary organic molecules concerning nanoelectrodes. In 1996 a breakthrough was recognized with carbon nanotubes. This was accomplished inside of a collaboration Together with the group of Nobel laureate Richard Smalley. STM and nanolithography approaches have been utilized to display that these nanotubes are quantum wires at the single-molecule stage, with excellent Actual physical Qualities.
[fourteen] In 2005 Dekker became involved with Netherlands-broad conversations about Intelligent Layout, a motion that he has given that Evidently distanced himself from. Dekker advocates that science and religion are certainly not in opposition but may be harmonized.
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2013, managed shaping of Reside bacterial cells into arbitrary styles; and discovery of spontaneous fluctuations inside the handedness of histone tetrasomes